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الجمعة، 9 أغسطس 2013

Obesity Management

Obesity is becoming a global problem. The majority of Australians are overweight, and 20% are obese. Professor Jeffrey Hamdorf talks about the problems caused by obesity and the possible treatments for obesity.

Video: Obesity managementYou would probably be aware that the health problems associated with excessive weight have been increasing in the Western world, particularly over the past two decades or so. The health problems we are talking about here include an increased risk of heart disease and high blood pressure (which can in turn cause stroke); also, there is a very high risk of developing diabetes and other problems with breathing such a sleep apnoea and asthma, and some digestive disorders as well. Overweight people have problems with mobility and they are at risk of developing diabetes affecting, especially, the weight bearing joints, like the ankles and knees. Fertility is affected, especially in women; this means that women which are overweight have a smaller chance of getting pregnant.

Obesity is regarded as morbid obesity when it reaches a point where there is a significant risk to health – and we can calculate and index for people. This is called the body mass index and it takes into account your weight and height. We are talking about morbid obesity, but this relates to people who have significant illnesses related to their weight, or who are in the order of 40 kilograms overweight. Obesity is a chronic illness and it does require significant treatment.

Now the reasons for obesity are many – it’s not simply a result of over eating. Once a patient becomes morbidly obese, a change in lifestyle – such a calorie-controlled diet – and increasing exercise is really important, but these have a limited effect on morbid obesity. Patients just can’t seem to lose enough weight using a diet approach alone to correct their health problems.

The principals for those that are overweight, but perhaps not obese, include a supervised diet and exercise program and this is entirely appropriate and there are many of these programs around. Unfortunately, these are not entirely suitable for obese patients, and particularly morbidly obese patients, because in over 90% of cases the weight lost in supervised programs is resumed within a couple of years. Once a patient’s weight is classified in the obese category then diet and lifestyle changes are not enough and medications may need to be added. There are two major medications in this area; they include Reductil, or Sebutramine, and Xenical, or Orlistat. These medications have to be offered under medical supervision.

Now another method which is successful in obese patients is cognitive behavioural therapy. This is group therapy supervised by a clinical psychologist and it looks at the reasons behind the peoples’ troublesome eating habits. This is available in Australia through general practitioner initiated care plans, so a GP needs to organise it.

For those patients that have morbid obesity (those people who are more than 40 kg overweight) or that have health problems created or made worse by their weight, then surgery is the mainstay treatment. Surgical procedures are based on reducing the amount of food one is able to eat before fullness occurs, or – and these are called reductive procedures – an old fashioned gastric stapling and more recently, a laparoscopic adjustable band or lap band. With the laparoscopic banding, a silicone band is placed around the top part of the stomach creating a small upper pouch. The band can be made tighter or looser depending on the weight loss, and this operation is one that is almost always done using the keyhole technique. The band can be adjusted and can be reversed if necessary. This is a method that helps people keep a sensible calorie-controlled diet and if it is reversed, more patients will resume their weight rather quickly. Another method which is gaining some popularity is called a sleeve or tube gastrectomy where a part of the stomach is surgically removed so that one is able to eat less. None of these methods tell a patient what to eat so we need to be fairly conscious about diet and for all surgical care of weight loss, a team approach is necessary with advice for the patient coming from a physician as well as a surgeon, a dietician, and sometimes a psychiatrist or a psychologist as well. Some teams use an exercise physiologist or a specialist physiotherapist to help design supervised exercise programs according to patients' needs.

More extensive surgery includes a procedure, which is particularly popular in the United States, called a Roux-en-Y gastric bypass. In this operation, the stomach is cut at the top portion leaving a small pouch and this is then connected to the intestine lower down; only small amounts of food may be eaten and these small amounts of food may take some time before they get to the digestive part of the bowel. That means that if the patient eats the wrong sorts of foods then they would experience significant indigestion symptoms. In addition to this, they will require daily nutritional supplements such as vitamins and minerals. Surgery for weight loss is very successful in a patient who is well prepared and well motivated to succeed, and most patients can expect to lose up to 60% of their excess weight. We find that this helps to correct the diabetes very quickly, patients sleep better and are much more mobile, improving their quality of life. Surgery is an important part in weight control and it should only be considered where a multidisciplinary team is used to help supervise patient care.

Fitness
For more information on measures of weight and nutrition, including GI, GL, BMI, WC and WHR, as well as some useful tools, see Measures of Nutrition and Weight. Obesity and weight loss
For more information on obesity, health and social issues, and methods of weight loss, as well as some useful tools, see Obesity and Weight Loss.

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الخميس، 8 أغسطس 2013

GORD: Managing the Symptoms


Gastro-oesophageal reflux disease (GORD or GERD) is a common and chronic gastrointestinal disorder. Nearly 80% of the population will experience symptoms of reflux at some stage in their lives. GORD is associated with prolonged exposure of the lower oesophageal mucosa to gastric contents, leading to symptoms of heartburn, regurgitation (feeling like the stomach contents are coming back up) and waterbrash (excess saliva in the mouth). Symptoms are often made worse by lying flat, are related to meals (especially fatty foods), and may be worsened by hot liquids or alcohol.

The severity of your symptoms does not always correspond to how badly your oesophagus is scarred or damaged. It is therefore important that you see a doctor so your condition can be properly investigated. GORD often requires life-long and regular use of anti-reflux therapies.

Treatment tends to pursue three main aims:

Healing the damage to the oesophagus;Preventing complications such as Barrett's oesophagus, strictures (narrowing), and oesophageal cancer; andAlleviating your symptoms and improving your quality of life.


In general, a step-wise approach is used in the management of GORD symptoms. Usually you will be trialled on simple lifestyle measures, and then slowly have more aggressive treatments added if your symptoms don't improve.

Before starting anti-reflux therapies, it is important that other causes of similar symptoms have been excluded. In particular, cardiac chest pain from angina can present quite similarly to reflux. Failure to treat an underlying heart problem could have serious consequences.

Managing GORD symptomsIf your GORD is mild it is likely that you will respond satisfactorily with simple lifestyle changes and over-the-counter antacids. In many cases, people are able to control their own symptoms and do not necessarily need to see a doctor. It is quite common for people to go to the doctor only when their symptoms become so severe that they interfere with daily functioning. However, it is important that you realise that reflux symptoms may be a marker of more serious underlying conditions. GORD can cause nasty complications, including oesophageal cancer, which need to be monitored throughout your treatment. In general, the longer you have symptoms of reflux, the greater risk you have for additional complications.

There are a number of symptoms that may suggest more serious problems and require urgent investigation. These are referred to as "alarm symptoms". It is important to see your doctor so they can conduct further investigations if you notice any:

Difficulty swallowing; Pain when swallowing;Blood in your vomit;Dark, tarry stools (melaena); Weight loss; Anaemia: You may notice you are more pale (particularly in the skin creases and conjunctiva of the eyes), or fatigue more easily.


Lifestyle changes

Lifestyle changes that can help manage GORD symptoms include:

Losing weight (if you are overweight); Elevating your head in bed; Avoiding lying down or sleeping for 3 hours after a meal; Reducing alcohol consumption; Quitting smoking;Avoiding fatty foods and foods that typically trigger symptoms, such as: Avoiding medications that trigger your reflux symptoms (discuss with your doctor).


Although some of these lifestyle changes can be difficult to achieve, they are excellent therapies as they are low cost and have few side effects. These measures are recommended for virtually everyone with GORD and should be continued even when using other therapies.


Over-the-counter and antacid therapy

Managing GORD symptomsDepending on the severity of your symptoms, your doctor may prescribe medications or recommend over-the-counter (OTC) preparations. These may be needed for a short time while you have symptoms or on a long-term basis, depending on the features of your symptoms.

Many people self-treat themselves with over-the-counter medications. These include simple antacids and alginates. Antacids work by neutralising the gastric acid so that it is no longer damaging to the oesophagus. Alginates, on the other hand, work by forming a thick gel coating on the surface of the stomach contents to stop them from refluxing. Lots of studies have confirmed these agents produce rapid symptom relief, but their effects only last for a short time so they need to be taken frequently. Furthermore, these treatments do not change the underlying amount of acid secretion or prevent complications, so they may be a more temporary measure.

Histamine-2 receptor antagonists (H2RA) such as cimetidine (e.g. Tagamet) and ranitidine (e.g. Zantac) are also available over-the-counter. These agents have been proven in clinical trials to reduce gastric acid levels. The different drugs of this class vary slightly in their potencies and onset of action. H2RAs can be taken before activities known to trigger reflux, such as eating heavy meals or exercising, to prevent the onset of symptoms.


Antisecretory medications

Suppressing the amount of acid produced in the stomach has been shown to be the most successful treatment for GORD. Proton pump inhibitors (PPIs) work by inhibiting a special enzyme on the surface of acid-producing cells in the stomach. This blocks acid production and reduces the overall level of acid in the stomach. PPIs are considered the most effective medications for symptom relief and may be used in nearly all cases, except perhaps if your disease is very mild. PPI medications are available via a prescription from your doctor.

PPI drugs available in Australia include:

Pantoprazole (Somac); Rabeprazole (Pariet); Omeprazole (Losec);Esomeprazole (Nexium);Lansoprazole (Zoton).


Clinical trials have confirmed that these medications treat symptoms such as heartburn, acid regurgitation and painful swallowing. They are effective in approximately 80% of patients. PPIs are able treat symptoms and heal oesophageal damage more rapidly than any other therapy available. There is still debate over which PPI is the most effective, so different doctors may prescribe different medications based on their experience.

If you have severe reflux, you will probably be treated long-term with a PPI medication. Often the maintenance dose is smaller than that prescribed in an acute period of symptoms. If you are on long-term treatment and suddenly stop taking your medication, it is likely you will experience a recurrence or relapse in your symptoms. Even with adequate therapy, it is not uncommon to have some occasional flares of symptoms. PPI medications should be taken before meals, as prescribed by your doctor. Usually the daily dose will be split into a morning and evening dose.

PPI medications are generally well tolerated and tend to have few side effects. However, the following adverse effects may occasionally occur (in approximately 5 out of 100 patients taking these medications):


Most side effects are only mild and temporary during the start of treatment. A more serious side effect of vitamin B12 deficiency has been reported, but this is exceedingly rare. Overall, PPIs are excellent medications in terms of efficacy and minimal side effects. Perhaps the only factor limiting more widespread use is cost, as some of the agents can be quite expensive.


Prokinetic medications

Some drugs such as metoclopramide and domperidone (Motilium) may be used as add-on therapies to help control symptoms. These agents work by enhancing the contractions of the stomach and increasing its rate of emptying. This essentially reduces the contents of the stomach so that less is available to reflux back into the oesophagus, thus reducing damage. 


Surgery

Surgery is usually only used in cases of very severe reflux symptoms, particularly in younger patients who would otherwise need long-term drug therapy to manage symptoms. Approximately 80% of patients undergoing surgery will demonstrate improvement in symptoms. However, controversy exists over the long-term effectiveness of this mode of treatment, and indications for surgery are less clear-cut than for other types of treatment.


Endoscopic therapy

Occasionally reflux symptoms may be treated endoscopically by inserting a tube down the throat and either sewing, burning or injecting damaged areas of the mucosa (lining). Unfortunately the long-term efficacy of these treatments is unknown so their role is limited to a very select number of patients. In addition, endoscopic treatment can cause significant complications such as pain, gastrointestinal injury and short-term dysphagia.

Managing GORD symptomsReflux is a very common condition in children but the symptoms are often non-specific. To date there is no ideal method of diagnosing or treating the problem in infants and children. However, you may gain some comfort from knowing that the symptoms of reflux are extremely common and that the condition is not due to any fault on your part. Often simple reassurance from a medical practitioner is helpful in improving both your and your child's quality of life.

As demonstrated above, there are many different treatments available for symptoms of reflux. Unfortunately there is limited experience with these therapies in children. Therefore when considering treatment for your child it is very important that you consider the potential side effects of the medications. You should remember that mild reflux is generally not a serious condition and that your child is otherwise well and healthy.

In most cases, symptoms of reflux will resolve spontaneously by approximately 12 months of age. Your doctor can help explain the condition more so that you understand that it is usually better for your child NOT to have extensive investigations or multiple drug therapies. This will avoid unnecessary side effects from unnecessary treatments.

Some management options for reflux symptoms in children are:

Reassurance and education: Learning more about your child's condition can allay some of your fears about the seriousness of the condition. Support groups such as RISA can help provide reassurance and educational materials; Posturing: There is some evidence that being in certain positions while feeding increase the incidence of reflux. Laying your child prone (on their stomach) with their head slightly elevated during feeding is associated with the least amount of reflux. It can be helpful to keep your child upright for about half an hour after feeds. However, caution should be taken positioning your child on their stomach, as there is an increased risk of SIDS;Dietary treatment: Milk thickeners and thickened feeds can reduce regurgitation, but there is limited evidence that they reduce reflux. Infants with mild acid reflux may respond well to simple thickening of their feeds; Alginates: There is limited experience with antacids in infants, but they may have some benefit in improving symptoms of mild GORD. However, side effects on bone metabolism (including rickets), diarrhoea and constipation can occur from these medications; Proton pump inhibitors: These are the recommended treatments for severe reflux in children. These treatments can cause side effects which should be discussed with your doctor. The pros and cons of treatment should be weighed up on an individual basis.


Children with very severe reflux symptoms and persistent vomiting can develop more serious complications such as failure to thrive and malnutrition. In these cases, more drastic measures may be required such as feeding through a nasogastric tube (a tube passed through the nose and down into the stomach, through which nutrient-rich puréed foods can be fed) or, very rarely, surgery.

Acid reflux and heartburn
For more information on acid reflux and heartburn and related investigations, treatments and supportive care, see Acid Reflux and Heartburn.

Biddle W. Gastroesophageal reflux disease: Current treatment approaches. Gastroenterol Nurs. 2003;26(6):228-36. [Abstract]DeVault KR, Castell DO. Updated guidelines for the diagnosis and treatment of gastroesophageal reflux disease. Am J Gastroenterol. 2005;100(1):190-200. [Abstract | Full text]Goyal R. Diseases of the esophagus. In: Braunwald E, Fauci AS, Kasper DL, et al. Harrison's Principles of Internal Medicine (15th edition). New York: McGraw-Hill Publishing; 2001. [Publisher]Ip S, Bonis P, Tatsioni A, et al. Comparative effectiveness of management strategies for gastroesophageal reflux disease [online]. Rockville, MD: Agency for Healthcare Research and Quality (AHRQ), US Department of Health and Human Services; 13 December 2005 [cited 10 June 2007]. Available from: URL link Kumar P, Clark M (eds). Clinical Medicine (5th edition). Edinburgh: WB Saunders Company; 2002. [Publisher] Somac [online]. MIMS Online; 2003 [cited 10 June 2007]. Available from: URL link Tutuian R. Castell DO. Management of gastroesophageal reflux disease. Am J Med Sci. 2003;326(5):309-18. [Abstract]Vandenplas Y. Gastroesophageal reflux: Medical treatment. J Pediatr Gastroenterol Nutr. 2005;41 Suppl 1:S41-2. [Full text] 

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Spinal Cord Stimulation Devices

Spinal cord stimulationSpinal cord stimulation (SCS) is an emerging, minimally invasive procedure used to treat chronic, refractory, neuropathic pain. Neuropathic pain is one of the most difficult medical conditions to treat; it is not the "normal" pain we associate with stubbing a toe or getting a paper cut – this is nocioceptive pain. Neuropathic pain is caused by abnormal nerve signalling in the nervous system and, as a result, commonly does not respond to most pain relief strategies. It is for this reason that SCS is a very exciting area of development and is becoming widely accepted for use in many areas of neuropathic pain management. SCS does not eliminate pain but creates a numbness called paraesthesia in the area. This results in a masking of the pain.

SCS involves implanting electrodes into the epidural space near the source of pain. Different levels of the spinal cord innervate different areas of the body. For example, the nerves that supply the fingers exit the central nervous system at one level of the spinal cord, and the nerves that supply the toes exit at a different level. Therefore if the pain is experienced in the chest area, the electrodes will be placed at the level of the spinal cord where the nerves emerge to innervate the chest. The electrodes are connected to wires or leads threaded through the epidural space. The leads transmit the electric current that stimulates the pain inhibition pathways; this is powered by an external or internal source, known as the neuromodulator. The power is supplied in pulses that are adjusted to suit the individual's paraesthetic needs.

Devices used in SCS include:

Electrodes;Leads;Neuromodulator; andProgrammer.Spinal cord stimulation 
For a general overview on SCS, including more information on the mechanisms behind paraesthesia, and the indications, costs, advantages, risks and contraindications of SCS, see Spinal Cord Stimulation. 

SCS evokes paraesthesia by transmitting electric pulses through connecting leads to the electrodes. The electrodes are implanted in the epidural space at the level of the spinal cord, which innervates the area where the pain is experienced.

The number of electrodes used is determined by the level and complexity of the pain experienced. A more widespread, higher degree of pain requires more electrodes to be placed in the epidural space. More electrodes placed in the spinal cord provides more paraesthesia options, because not all electrodes are stimulated at all times.

The electrode stimulation pattern is controlled externally and each pattern will induce a slightly different sensation, some of which will provide more pain relief than others. If more electrodes are available, the number of pattern combinations that can be tested is increased. In order to expand these stimulation options further, a multi-array of electrodes is situated at the ends of the leads; usually this comprises of 4, 8 or 16 electrode contacts.

The leads are responsible for transmitting the electrical pulses generated by the neuromodulator to the electrodes, which are located at the end of the leads. The leads are thin wires inserted via a needle into the epidural space.


Paddle leads

The surgically implantable leads have a paddle-shaped electrode multi-array attached to the end, making them comparatively large compared to others available. Paddles provide an extensive coverage of the area and are used for more severe pain.


Percutaneous leads

Percutaneous leads have a slimmer design than paddle leads, which allows them to be easily manipulated and controlled. These leads are best for pain that is unusually dispersed and therefore requires more unusual overlap of paraesthesia benefits. Percutaneous leads are cheaper, faster and easier to insert and remove. For these reasons, these leads are commonly used for the trial period between electrode placement and generator implantation, although they carry a greater risk of infection and lead migration.

Percutaneous leads consume more battery power than paddle leads, and therefore require more frequent battery replacements or recharging.

The neuromodulator is the power source of the stimulator system. It can be either internally implanted, acting as a generator; or remain external, with transmission occurring via a radiofrequency system coupled to an internally implanted receiver. The neuromodulator produces the electric currents that are then transmitted to the spinal cord. All systems can control up to 16 electrodes per lead, giving rise to many stimulating patterns.

The choice of neuromodulator is entirely dependent on the individual's requirements and preferences. The predominant concerns dictating the choice are:

The need for controllability of the system; and The need for substantial power deliverability to stimulate adequate stimulation.


Convenience, financial and cosmetic factors for the individual are also taken into account.


Radiofrequency systems

The radiofrequency system operates by sending radio waves in pulses to the implanted receiver. As radiofrequency systems are not dependent on internal battery activation and require more power than other systems, they work best for people with high stimulation requirements and the most complex and intense pain. This is because when the stimulatory needs are greater, the battery will need to be replaced more frequently. Radiofrequency systems are powered by an external transmitter, which carries the battery, and is therefore easily replaced without invasive surgery.

The radiofrequency system is not as aesthetically pleasing as a fully implanted device, as an antenna and transmitter must be worn externally. In addition, the antenna can cause irritation.


Implantable pulse generator 

Implantable pulse generators (IPGs) are powered by an internal battery and must be replaced once it runs out. Recent developments have improved the size and battery life of IPGs.

Primary cell IPGs are similar to conventional implantable neuromodulators. They are suited to people who cannot operate a rechargeable system or do not require one. The batteries are high powered and have a life of up to 10 years, depending on use. The IPG can be implanted 2.5 cm under the skin. When the battery does need to be removed, it is a very minor procedure.


Rechargeable implantable pulse generator

The smallest neuromodulator currently available (10 mm wide and weighing less than 30 g) is a completely rechargeable implantable pulse generator, allowing the device to be used for a longer period. This means less invasive operations and a greater cost benefit. With a greater battery life, there is no need for major concern about conserving power on a day to day basis, and people implanted with this system should feel as though they can use the device as much as required. The remaining battery life is monitored by a controller. When the controller displays indicates low battery, the system needs to be recharged.

The device is completely implanted under the skin at a depth of about 2.5 cm. The battery is recharged via an externally controlled radiofrequency system. How often the battery must be recharged depends on use. Eventually, a point will be reached when the battery life per recharge will not last long enough for routine activities. It will then need to be surgically replaced.

Rechargable IPGs provide an alternative option for people with energy needs too high for the primary cell IPG, and whose only option in the past was radiofrequency systems. Substantial power requirements are still best served by radiofrequency.

The programmer provides a non-invasive way of adjusting the stimulator settings, or turning off the system completely. For some people, the effects of the stimulation can last for up to a week after the power is shut down.

When the system is turned on, the programmer allows electrode activation and pulse parameters to be selected. The pulse parameters are the timing between pulses, and the length of each pulse delivered to the electrodes. There will be a range of pulse parameters that can induce an adequate level of pain relief for each person.

The initial pulse parameter limits are set up by the doctor. Subsequently, the pulse parameters can be controlled and adjusted on a day to day basis by the person implanted with the system. The limits are put in place for safety, so the parameters cannot accidently be set too high or too low when not supervised by the doctor.

In the past, the settings on programmers were adjusted manually by the doctor, allowing only a small number of possible combinations to be trialled due to the relatively slow process of manual adjustment and limited time spent with the doctor. This has changed recently with increased research and development into the area. Programming is becoming more consumer interactive with the use of automated controls. This automated system allows the safe exploration of a larger array of contact combinations without supervision from the doctor.

The devices involved in SCS are continuously being improved, and as devices and implantation procedures become more technologically advanced, the treatment becomes even more cost effective and quality of life for those who receive SCS improves. Current research in the area is focused on further improving the effect of stimulation and expanding its compatibility to allow a broader range of people to be eligible for the treatment. Future aims include:

Increasing the number of contacts for each lead in order to better provide paraesthesia in the area;Designing the devices so they are compatible with MRI;Improving wireless options for control of the devices, for example through Bluetooth; and Improving lead delivery procedures in order to better target the spinal cord.Spinal cord stimulation
For more information about SCS, the conditions treated with SCS, SCS devices, and some useful videos and news, see Spinal Cord Stimulation.

International Neuromodulation Society
St Jude Medical website

Chronic pain management and pain relief

www.poweroveryourpain.com 


The Power Over Your Pain website provides information about neurostimulation and helps you connect with others who are experiencing the benefits of the treatment.

http://www.poweroveryourpain.com/

North R, Shipley J, Prager J, et al. Practice parameters for the use of spinal cord stimulation in the treatment of chronic neuropathic pain. Pain Med. 2007;8(Suppl 4):S200-75. [Abstract]Spinal cord stimulation [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Bala MM, Riemsma RP, Nixon J, Kleijnen J. Systematic review of the (cost-)effectiveness of spinal cord stimulation for people with failed back surgery syndrome. Clin J Pain. 2008;24(9):741-56. [Abstract]North RB, Calkins SK, Campbell DS, et al. Automated, patient-interactive, spinal cord stimulator adjustment: A randomized controlled trial. Neurosurgery. 2003;52(3):572-80. [Abstract]Tripole paddle leads [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Kreis PG, Fishman SM, Chau K. Impact to spinal cord stimulator lead integrity with direct suture loop ties. Pain Med. 2009;10(3):495-500. [Abstract]North NB, Wetzel FT. Spinal cord stimulation for chronic pain of spinal origin: A valuable long-term solution. Spine. 2002;27(22):2584-91. [Abstract]Percutaneous leads [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link EonC primary cell IPG system [online].Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Genesis primary cell IPG system [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Eon rechargable IPG system [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Eon Mini rechargable IPG system [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link NeuroDynamix [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Rapid programmer (R) 3.0 [online]. Plano, Texas: St Jude Medical; 2009 [cited 25 August 2009]. Available from: URL link Mekhail NA, Cheng J, Narouze S, et al. Clinical applications of neurostimulation: Forty years later. Pain Pract. 2010;10(2):103-12. [Abstract]
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الأربعاء، 7 أغسطس 2013

Just weight until menopause

Women tend to carry excess fat in their hips and thighs, while men tend to carry it on their stomachs. But after menopause, things start to change: many women's fat storage patterns start to resemble those of men. This indicates that there's a link between estrogen and body fat storage. This connection is well documented, but the underlying mechanisms remained poorly understood until now.

New research conducted by Sylvia Santosa, assistant professor in Concordia University's Department of Exercise Science and Canada Research Chair in Clinical Nutrition, gives us a new look at the connection between fat storage and estrogen. By examining the fat storage process at a cellular level, Santosa and co-author Michael D. Jensen of the Mayo Clinic in Rochester, Minnesota, reveal that certain proteins and enzymes are more active in post-menopausal women. These proteins correspond with fat storage. Their findings were published in the March 2013 issue of Diabetes.

"The fat stored on our hips and thighs, is relatively harmless," explains Santosa, who is also a member of Concordia's PERFORM Centre for better health through prevention. "But the fat stored around the abdomen is more dangerous. It has been associated with diabetes, heart disease, stroke and even some cancers. When post-menopausal women put on more abdominal fat, they dramatically increase their risk for these health problems. Given these dangers, it is very important to understand the how the lower levels of estrogen associated with menopause changes where fat is stored."

Santosa's research compared fat storage in pre- and post-menopausal women. The 23 women who participated in the study were in the same age range, and had similar Body Mass Indices and body fat composition. These similarities allowed Santosa to isolate the effects of estrogen on fat absorption and storage.

She and Jensen were able to examine the activity of certain enzymes and proteins that regulate fat storage in post-menopausal women's abdomens and thighs. By considering these factors together rather than in isolation, the researchers determined conclusively that the overall fat storage "machinery" is more active in post-menopausal women. In other words, these cells now store more fat than they did before menopause.

In addition, post-menopausal women burned less fat than their pre-menopausal colleagues. These changes mean that their cells are not only storing more fat, but are also less willing to part with it. This combination is a recipe for rapid weight gain. "Taken together, these changes in bodily processes may be more than a little surprising – and upsetting – for women who previously had little trouble managing their weight," comments Santosa.

Though the increased cellular activity revealed by this study was not specific to the abdominal region, more fat stored overall means more abdominal fat. Evidence of changes in the fat storage pathways after menopause is an important contribution to understanding why post-menopausal women begin to put on more visceral fat.

Says Santosa, "the information revealed by our study is valuable not only to post-menopausal women and their doctors, but to obesity studies more generally. A clearer picture of which proteins and enzymes increase fat storage makes those productive targets for future medical advances in the fight against obesity."


(Source: Concordia University : Diabetes)

MenopauseFor more information on menopause, including symptoms and management of menopause, as well as some useful animations and videos, see Menopause.
Obesity and weight lossFor more information on obesity, health and social issues, and methods of weight loss, as well as some useful tools, see Obesity and Weight Loss.
calendar icon Article Date: 11/4/2013
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Easy Workouts to Lose Weight

If you think you have to exercise to the point of exhaustion every day to lose weight, you’re wrong. In fact, easy workouts are essential if you want to burn fat and lose weight with exercise. But how you set up your easy workout plan depends on your workout history.

Beginning and advanced exercisers use easy workouts differently. For beginners, low intensity exercise lays the groundwork for building a fitness program. If you are new to exercise or if you’ve had no luck maintaining an exercise program, start with a program of easy weight loss workouts. But if you are an intermediate or advanced exerciser, use easy exercise on your active recovery days.

An active rest day, or a recovery day, is part of a complete workout program that includes high intensity, moderate intensity and low intensity exercise. During the low intensity recovery days you still exercise, but you keep your heart rate low (no higher than 70% of your maximum heart rate) and focus on activities that loosen the muscles, increase your range of motion, and allow your body and mind to recover from more intense sessions.

During a typical week, you should schedule a recovery day after each high intensity workout day. So, if you do high intensity intervals on Mondays and Thursdays, you should schedule easy workouts for Tuesday and Friday. If you do a high intensity workout on Sunday, make Monday your active rest day.

Weight Loss Benefits of Easy Workout Days

It’s tempting to flop on the couch the day after a high intensity exercise session, but if you’re trying to lose weight, you should choose to do an active recovery workout instead. The weight loss benefits add up.

Burn calories. Even low intensity exercise burns calories, especially if you compare it to sitting on the couch. You may only burn 200 calories during your easy workout, but over the course of an eight-week exercise program, that adds up to almost 3500 extra calories burned or one extra pound of weight lost if you do it twice per week Build/Maintain Consistent Workout Schedule. The hardest part of starting an exercise program is building a new routine. You’ll build the routine faster if you get into the habit of exercising every day. With active rest days, you are more likely to be able to maintain a daily exercise habit. Increased Range of Motion. Active recovery days are great opportunities to do exercises and activities that use your muscles in new and different ways. This helps to create a healthy balanced body that remains injury-free for more intense calorie-blasting workouts. Decrease Stress. Easy workouts should make you feel good. They are a great way to blow off steam and avoid emotional binge eating.

Easy Workout Ideas

There are countless options for your active recovery days. To maximize the health benefits of your fitness program, try to do easy workouts with muscles that are different than the ones you use during your hard day workouts, or that stretch the muscles that are tired and sore. For example,

if you complete a high intensity run on Monday, a good rest day workout might include a walk. Even though you are still using your legs, walking focuses on the muscles in the back of your legs (glutes and hamstrings) and walking lengthens the hip flexors that tighten when you run. if you ride your bike to lose weight, try swimming or yoga on your recovery day. Cycling primarily works the lower body. Swimming and yoga help build upper body strength and depending on how you do the workout, can help to increase range of motion in your legs.If you completed a high intensity circuit workout, use your easy exercise day to focus on flexibility and stretching. Take a dance class, do restorative yoga, or aqua jog for 20 minutes followed by 10 minutes of poolside stretching.

The Best Recovery Day Workout

The best recovery day workout is the one that you do. Remember, the purpose of this easy workout is not just to burn calories, but it is to help you to maintain a consistent daily exercise program. Rest days are also opportunities to destress and give your mind a break, so don't worry about doing the right workout or the right exercise. Just do something. If you do a workout, any workout, no matter what it is, you’ve gained a benefit.


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Basal Metabolic Rate

Definition: Basal metabolic rate (BMR) refers to the minimum amount of energy -- in the form of calories -- that your body requires to complete its normal functions, such as breathing, breaking down food, and keeping your heart and brain working. Age, gender, weight, and physical activity directly effect on basal metabolic rate.

BMR varies from person to person and increases with your amount of muscle tissue. Exercising increases your BMR, and it can stay raised after 30 minutes of moderate physical activity. Many people's BMR stays increased for approximately 48 hours following exercise.

Common Misspellings: basil metabolic rateBasal metabolic rate is typically reduced as we age.

Weight Loss Glossary


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10 Tips for Eating Out on a Diet

women eating Focus on your friends, not the food, and you'll enjoy eating out on a diet even more.

© [2009] Jupiterimages Corporation Eating out on a diet doesn't have to be cause for panic. Sure, you hear about oversize restaurant portions and the plethora of fattening menu choices available all the time, but that doesn't mean dining out will doom your dieting efforts! Just use these 10 simple tips for eating out on a diet: Cram for tonight's dinner. Many eateries post their entire menu online so you can print it out for reference. If you often eat at "mom and pop" type restaurants that aren't online, call and ask for the menu to be faxed to you, or pick up a takeout menu on your next visit. Highlight the healthiest options for each menu and store them all in a central location. Then, when you are planning your next night out, take the time to decide on your dishes at home before you've been tempted by the sight of other choices. Order your main dish from the appetizer menu. Not only are appetizers more reasonably-portioned, they will save you some money as well. (This is a great way to save enough calories and cash to split dessert with someone!) Too peckish to be satisfied with just a starter? Order a side salad, too -- the fiber-rich veggies will round out your meal. Soup is super-filling, so it's an awesome appetizer add-on, too (just steer clear of cream-based ones).Beware these high-fat menu buzz words: Cream sauce, butter, oil, au gratin, breaded, Alfredo, battered or batter-dipped, "with gravy," or smothered. Unless you've spared yourself treats for several days and snacked on salad greens all day, these little "extras" aren't worth the extra calories.Modify the menu. In my neck of the woods, anything and everything can be batter-dipped and fried, so I make special requests all the time. Many restaurants will take your dietary needs into account so you'll be a happy customer and return. Don't hesitate to request anything on the menu to be prepared in a more diet-friendly and for sauces or dressings to be served on the side. It's not likely that you will be denied.The meat is on. As tempting as that bucket of fried chicken looked on the commercial before you left home, order poultry steamed, poached, roasted, broiled, boiled, grilled or baked. Ask for skinless chicken whenever possible or remove it yourself. If you do treat yourself to fried chicken, choose white meat as it has fewer calories than dark. Of course, chicken, chicken and more chicken gets old after a while, so if you're asking, "Where's the beef?" allow yourself red meat a few times a week -- just be sure to choose leaner cuts of meat like loin or flank.Keep tabs on that tubini. Endless pasta at your favorite Italian restaurant may be carb-lovers' heaven (Darn near nirvana for yours truly!), but it's a waist-widening trap for those of us who tend to overeat (How are you supposed to know when to say "when" if they keep bringing more?). As tempting as the great "value" for your money that infinitely-refilling pasta bowl seems, it's certainly not a bargain for your calorie budget. Order a portion-controlled main dish instead. "Ixnay" on the endless breadsticks, too! "Wrap it up, I'll take it!" You know you're at a nice restaurant when the server takes your plate away and wraps up your leftover food for you at the end of the meal. (And if you're in a really nice restaurant, you'll get the eating out equivalent of a balloon animal -- the tin foil swan!) To ensure you don't leave sans swan, keep temptation at bay and ask the server to wrap up half of your as soon as it is served.Take control of takeout. You don't have to swear off takeout when you're dieting -- there are many healthy options at ethnic restaurants. Portion control is key, though: Take out half of your takeout before dishing up your dinner, put the food in microwave containers and tuck it away in the fridge before you even start eating. (Instant will power and instant next-day lunch!)Banish buffets. Portion control can become a foreign concept for even the most determined dieter at an all-you-can-eat buffet. (Who can practice moderation when there are new, clean plates just beckoning to be filled?) The sheer variety of foods available at buffets is also daunting -- studies have shown that when we're given more choices, we tend to eat more without realizing it. Simply avoid buffet restaurants and you won't have to face this temptation.Mini meals are a must. It's smart to eat smaller meals during the day when you're planning to dine out. Just don't eat too sparingly, though -- you don't want to be so famished by the evening that you overeat. (It was a dark day when I ate too-mini mini meals and -- clearly ignoring my own tip number 9! -- visited a buffet in a ravenous state with a fellow waist-watcher ... the look of sheer horror on her face as I went for round number four is not something I will soon forget!) If mini meals don't tide you over, have a small, healthful snack in the afternoon to curb your appetite and you'll be much more in control come dinner time.

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الأحد، 4 أغسطس 2013

The Secret to Six-Pack Abs

I wish I had a nickel for every time a woman asked me how to get a flat stomach or six-pack abs. It's one of the most common fitness goals for women. Here's a tip: You can't go to the corner of the gym and do crunches until you're ready to throw up and expect to get flat abs... even if you do it 7 days a week. And who would want to do that, anyway?

Why doesn't this approach work? Because muscle doesn't own the fat on top of it. Hmmm. One more time: Muscle doesn't own the fat on top of it. Think about it. If you see a body builder standing in front of the mirror doing bicep curls, what do you think his goal is? I'll give you a hint. Do you think he is trying to make his bicep bigger or smaller? Why bigger, of course! So why is it, then, that so many people believe they can make their stomach smaller by working their abdominal muscles? Hopefully a light bulb just came on in your head. So then...

HOW DO YOU GET THAT LEAN LOOK?

By having the right body composition. A lean look (and six-pack abs) come from having low body fat. Truth is, everyone has a six pack. Some just have more layers of fat covering it than others. The key to getting a flat stomach is to set your sites on having less body fat so that your six pack can show.

You have three choices for defining your fitness goals as it relates to body composition. You can lose fat, build muscle, or maintain your body. There is a big difference between muscle and fat. For starters, one pound of muscle burns 35 - 75 calories a day. One pound of fat burns 8 calories per day. Whoa! That's what "muscle is calorie-burning machinery" means. Secondly, fat doesn't turn into muscle. They are two different things.

If you want six-pack abs, your goal is to lose body fat. To lose body fat, you must be in a caloric deficit. That simply means taking in less calories every day than you spend in energy. While you're doing that, you want to maintain your muscle mass with resistance training. This is when fat melts away from your body, effectively changing your body composition.

HOW DO YOU MAINTAIN A CALORIC DEFICIT?

You can lower your caloric intake and/or increase your caloric output. The basic formula for figuring caloric intake for a deficit is your current weight in pounds times 15 minus 500 equals the number of calories to eat per day. [Current Weight x 15 - 500 = Daily Caloric Intake] This is a basic formula that you may need to adjust based on your activity level and your current body composition (now that you know the difference between calories burned by muscle versus calories burned by fat). Any activity you can add to your daily routine will help increase your caloric deficit and give your body fat no choice but to melt.

It doesn't hurt to work your abs. Your abs are part of your core and a strong core will help you lessen the risk of injury and help you be stronger for your everyday life in and out of the gym. And once you see your six-pack starting to emerge, you will want them to "pop" and be more defined. However, crunches and ab machines are not the secret weapon for fighting belly bulge. Monitoring the amount of calories you eat is the key. Simply put, you can't out-exercise a bad diet.

Stacie Dickerson is the CEO of the Healthy Lifestyle Institute for Women. Access their free article archive, become a member absolutely free and get your health & fitness tools at  http://hliwconnect.com/.



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